Clustering_results_report
2024-01-30
1 Clustring Processed data without auxiliary variables
1.1 Imporved Deep Empedding Clustering on the asthmatic encoded data 3 clusters
1.1.1 Summary table
# results_Kam <- get_ClusterResults(OriginalData = my_imp_data, Labels = kamRes$finalMemb)
table_result <- tableby(clusters ~ ., data = as.list(results_cluster_data))
summary(table_result, title = "Charachtaristcs of Clusters") | 0 (N=955) | 1 (N=397) | 2 (N=543) | Total (N=1895) | p value | |
|---|---|---|---|---|---|
| Age | < 0.001 | ||||
| Â Â Â Mean (SD) | 42.671 (13.003) | 64.738 (9.984) | 51.131 (15.427) | 49.718 (15.717) | |
| Â Â Â Range | 17.000 - 76.000 | 20.000 - 97.000 | 18.000 - 86.000 | 17.000 - 97.000 | |
| Gender | 0.324 | ||||
| Â Â Â No | 375 (39.3%) | 173 (43.6%) | 216 (39.8%) | 764 (40.3%) | |
| Â Â Â Yes | 580 (60.7%) | 224 (56.4%) | 327 (60.2%) | 1131 (59.7%) | |
| BMI | < 0.001 | ||||
| Â Â Â Mean (SD) | 26.058 (4.348) | 29.129 (5.370) | 27.315 (4.891) | 27.062 (4.880) | |
| Â Â Â Range | 17.029 - 42.595 | 18.290 - 50.058 | 17.509 - 48.919 | 17.029 - 50.058 | |
| age at asthma onset as numeeric variable | < 0.001 | ||||
| Â Â Â Mean (SD) | 15.883 (12.318) | 33.378 (18.943) | 22.661 (18.147) | 21.490 (17.075) | |
| Â Â Â Range | -1.000 - 65.000 | 1.000 - 72.000 | -1.000 - 70.000 | -1.000 - 72.000 | |
| Cough | < 0.001 | ||||
| Â Â Â No | 708 (74.1%) | 202 (50.9%) | 347 (63.9%) | 1257 (66.3%) | |
| Â Â Â Yes | 247 (25.9%) | 195 (49.1%) | 196 (36.1%) | 638 (33.7%) | |
| Breathlessness | < 0.001 | ||||
| Â Â Â No | 349 (36.5%) | 121 (30.5%) | 148 (27.3%) | 618 (32.6%) | |
| Â Â Â Yes | 606 (63.5%) | 276 (69.5%) | 395 (72.7%) | 1277 (67.4%) | |
| Recurrent_wheeze | < 0.001 | ||||
| Â Â Â No | 811 (84.9%) | 257 (64.7%) | 414 (76.2%) | 1482 (78.2%) | |
| Â Â Â Yes | 144 (15.1%) | 140 (35.3%) | 129 (23.8%) | 413 (21.8%) | |
| dyspenea | < 0.001 | ||||
| Â Â Â No | 845 (88.5%) | 227 (57.2%) | 410 (75.5%) | 1482 (78.2%) | |
| Â Â Â Yes | 110 (11.5%) | 170 (42.8%) | 133 (24.5%) | 413 (21.8%) | |
| Chronic_productive_cough | < 0.001 | ||||
| Â Â Â No | 839 (87.9%) | 240 (60.5%) | 395 (72.7%) | 1474 (77.8%) | |
| Â Â Â Yes | 116 (12.1%) | 157 (39.5%) | 148 (27.3%) | 421 (22.2%) | |
| FEV1_FVC_ratio_post | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.798 (0.070) | 0.713 (0.117) | 0.763 (0.099) | 0.770 (0.096) | |
| Â Â Â Range | 0.484 - 1.009 | 0.230 - 1.028 | 0.340 - 1.590 | 0.230 - 1.590 | |
| Reversibility | < 0.001 | ||||
| Â Â Â Mean (SD) | 6.290 (6.394) | 8.949 (10.273) | 7.986 (7.254) | 7.333 (7.677) | |
| Â Â Â Range | -26.774 - 56.067 | -20.000 - 77.242 | -12.121 - 46.196 | -26.774 - 77.242 | |
| pd20 | < 0.001 | ||||
| Â Â Â Mean (SD) | 1658.220 (2670.652) | 2713.327 (1944.502) | 1913.705 (1867.254) | 1952.471 (2355.058) | |
| Â Â Â Range | -26261.250 - 38775.000 | 33.570 - 12925.000 | -3701.250 - 12925.000 | -26261.250 - 38775.000 | |
| tlco | < 0.001 | ||||
| Â Â Â Mean (SD) | 106.436 (13.513) | 84.804 (14.838) | 100.286 (20.709) | 100.142 (18.166) | |
| Â Â Â Range | 67.252 - 230.491 | 44.453 - 136.837 | 44.477 - 389.709 | 44.453 - 389.709 | |
| kco | < 0.001 | ||||
| Â Â Â Mean (SD) | 103.638 (12.339) | 86.290 (14.706) | 100.040 (15.815) | 98.972 (15.443) | |
| Â Â Â Range | 69.265 - 144.168 | 43.704 - 139.418 | 40.972 - 149.720 | 40.972 - 149.720 | |
| FeNO | < 0.001 | ||||
| Â Â Â Mean (SD) | 23.923 (19.303) | 24.737 (23.752) | 28.865 (25.828) | 25.509 (22.386) | |
| Â Â Â Range | 3.300 - 203.000 | 3.600 - 193.000 | 5.000 - 226.000 | 3.300 - 226.000 | |
| Eosinophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.186 (0.130) | 0.216 (0.184) | 0.281 (0.186) | 0.220 (0.165) | |
| Â Â Â Range | 0.000 - 0.900 | 0.000 - 2.300 | 0.040 - 1.200 | 0.000 - 2.300 | |
| Neutrophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 3.516 (1.142) | 4.204 (1.630) | 4.200 (1.427) | 3.856 (1.383) | |
| Â Â Â Range | 1.100 - 7.900 | 1.300 - 12.500 | 1.000 - 10.000 | 1.000 - 12.500 | |
| Lymphocyties | < 0.001 | ||||
| Â Â Â Mean (SD) | 1.914 (0.556) | 1.913 (0.758) | 2.154 (0.792) | 1.983 (0.683) | |
| Â Â Â Range | 0.600 - 4.800 | 0.300 - 8.000 | 0.700 - 11.200 | 0.300 - 11.200 | |
| Monocytes | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.386 (0.125) | 0.467 (0.195) | 0.468 (0.149) | 0.426 (0.154) | |
| Â Â Â Range | 0.200 - 1.000 | 0.200 - 2.400 | 0.200 - 1.100 | 0.200 - 2.400 | |
| Basophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.003 (0.009) | 0.006 (0.020) | 0.100 (0.020) | 0.031 (0.046) | |
| Â Â Â Range | 0.000 - 0.050 | 0.000 - 0.100 | 0.000 - 0.300 | 0.000 - 0.300 | |
| spt_any | < 0.001 | ||||
| Â Â Â No | 247 (25.9%) | 191 (48.1%) | 209 (38.5%) | 647 (34.1%) | |
| Â Â Â Yes | 708 (74.1%) | 206 (51.9%) | 334 (61.5%) | 1248 (65.9%) | |
| familial_allergy | < 0.001 | ||||
| Â Â Â No | 400 (41.9%) | 280 (70.5%) | 286 (52.7%) | 966 (51.0%) | |
| Â Â Â Yes | 555 (58.1%) | 117 (29.5%) | 257 (47.3%) | 929 (49.0%) | |
| Drug_induced_dyspnea | 0.054 | ||||
| Â Â Â No | 910 (95.3%) | 365 (91.9%) | 512 (94.3%) | 1787 (94.3%) | |
| Â Â Â Yes | 45 (4.7%) | 32 (8.1%) | 31 (5.7%) | 108 (5.7%) | |
| nasal_plyposis | 0.004 | ||||
| Â Â Â No | 577 (60.4%) | 209 (52.6%) | 287 (52.9%) | 1073 (56.6%) | |
| Â Â Â Yes | 378 (39.6%) | 188 (47.4%) | 256 (47.1%) | 822 (43.4%) | |
| Ever_rhinitis | < 0.001 | ||||
| Â Â Â No | 351 (36.8%) | 118 (29.7%) | 133 (24.5%) | 602 (31.8%) | |
| Â Â Â Yes | 604 (63.2%) | 279 (70.3%) | 410 (75.5%) | 1293 (68.2%) | |
| gina_steps | 0.003 | ||||
| Â Â Â onlys saba or non users | 653 (68.4%) | 278 (70.0%) | 352 (64.8%) | 1283 (67.7%) | |
| Â Â Â step 1 or 2 | 169 (17.7%) | 57 (14.4%) | 111 (20.4%) | 337 (17.8%) | |
| Â Â Â step3 | 61 (6.4%) | 16 (4.0%) | 19 (3.5%) | 96 (5.1%) | |
| Â Â Â step4 or 5 | 72 (7.5%) | 46 (11.6%) | 61 (11.2%) | 179 (9.4%) | |
| Hosptalization_last_year | < 0.001 | ||||
| Â Â Â No | 934 (97.8%) | 355 (89.4%) | 515 (94.8%) | 1804 (95.2%) | |
| Â Â Â Yes | 21 (2.2%) | 42 (10.6%) | 28 (5.2%) | 91 (4.8%) | |
| Emergency_last_year | < 0.001 | ||||
| Â Â Â No | 855 (89.5%) | 288 (72.5%) | 446 (82.1%) | 1589 (83.9%) | |
| Â Â Â Yes | 100 (10.5%) | 109 (27.5%) | 97 (17.9%) | 306 (16.1%) | |
| severe_asthma | < 0.001 | ||||
| Â Â Â No | 835 (87.4%) | 316 (79.6%) | 437 (80.5%) | 1588 (83.8%) | |
| Â Â Â Yes | 120 (12.6%) | 81 (20.4%) | 106 (19.5%) | 307 (16.2%) | |
| gina_control | < 0.001 | ||||
| Â Â Â controlled | 413 (43.2%) | 123 (31.0%) | 181 (33.3%) | 717 (37.8%) | |
| Â Â Â partially controlled | 440 (46.1%) | 195 (49.1%) | 257 (47.3%) | 892 (47.1%) | |
| Â Â Â uncontrolled | 102 (10.7%) | 79 (19.9%) | 105 (19.3%) | 286 (15.1%) | |
| education | < 0.001 | ||||
| Â Â Â primary | 540 (56.5%) | 130 (32.7%) | 240 (44.2%) | 910 (48.0%) | |
| Â Â Â secondary | 371 (38.8%) | 149 (37.5%) | 229 (42.2%) | 749 (39.5%) | |
| Â Â Â tertiary | 44 (4.6%) | 118 (29.7%) | 74 (13.6%) | 236 (12.5%) | |
| urbanization_level | < 0.001 | ||||
| Â Â Â No | 458 (48.0%) | 197 (49.6%) | 331 (61.0%) | 986 (52.0%) | |
| Â Â Â Yes | 497 (52.0%) | 200 (50.4%) | 212 (39.0%) | 909 (48.0%) | |
| smoking_status | < 0.001 | ||||
| Â Â Â never smoker | 610 (63.9%) | 149 (37.5%) | 270 (49.7%) | 1029 (54.3%) | |
| Â Â Â former smokers | 288 (30.2%) | 199 (50.1%) | 212 (39.0%) | 699 (36.9%) | |
| Â Â Â current smoker | 57 (6.0%) | 49 (12.3%) | 61 (11.2%) | 167 (8.8%) | |
| pack_years | < 0.001 | ||||
| Â Â Â Mean (SD) | 6.390 (6.942) | 24.371 (18.767) | 12.629 (13.694) | 11.945 (14.129) | |
| Â Â Â Range | 0.000 - 64.500 | 0.000 - 112.500 | 0.000 - 111.000 | 0.000 - 112.500 | |
| smoking_exposure_at_home | < 0.001 | ||||
| Â Â Â No | 408 (42.7%) | 121 (30.5%) | 190 (35.0%) | 719 (37.9%) | |
| Â Â Â Yes | 547 (57.3%) | 276 (69.5%) | 353 (65.0%) | 1176 (62.1%) | |
| smoking_exposure_at_work | < 0.001 | ||||
| Â Â Â No | 651 (68.2%) | 186 (46.9%) | 312 (57.5%) | 1149 (60.6%) | |
| Â Â Â Yes | 304 (31.8%) | 211 (53.1%) | 231 (42.5%) | 746 (39.4%) | |
| household_damage | 0.111 | ||||
| Â Â Â No | 824 (86.3%) | 359 (90.4%) | 474 (87.3%) | 1657 (87.4%) | |
| Â Â Â Yes | 131 (13.7%) | 38 (9.6%) | 69 (12.7%) | 238 (12.6%) | |
| exertion_triggered_asthma | 0.034 | ||||
| Â Â Â No | 365 (38.2%) | 163 (41.1%) | 180 (33.1%) | 708 (37.4%) | |
| Â Â Â Yes | 590 (61.8%) | 234 (58.9%) | 363 (66.9%) | 1187 (62.6%) | |
| infection_triggered_asthma | 0.033 | ||||
| Â Â Â No | 391 (40.9%) | 162 (40.8%) | 187 (34.4%) | 740 (39.1%) | |
| Â Â Â Yes | 564 (59.1%) | 235 (59.2%) | 356 (65.6%) | 1155 (60.9%) | |
| allergen_triggered_asthma | 0.067 | ||||
| Â Â Â No | 673 (70.5%) | 298 (75.1%) | 370 (68.1%) | 1341 (70.8%) | |
| Â Â Â Yes | 282 (29.5%) | 99 (24.9%) | 173 (31.9%) | 554 (29.2%) | |
| irritant_triggered_asthma | 0.308 | ||||
| Â Â Â No | 824 (86.3%) | 331 (83.4%) | 457 (84.2%) | 1612 (85.1%) | |
| Â Â Â Yes | 131 (13.7%) | 66 (16.6%) | 86 (15.8%) | 283 (14.9%) | |
| weather_triggered_asthma | 0.007 | ||||
| Â Â Â No | 677 (70.9%) | 271 (68.3%) | 342 (63.0%) | 1290 (68.1%) | |
| Â Â Â Yes | 278 (29.1%) | 126 (31.7%) | 201 (37.0%) | 605 (31.9%) | |
| emotion_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 891 (93.3%) | 366 (92.2%) | 475 (87.5%) | 1732 (91.4%) | |
| Â Â Â Yes | 64 (6.7%) | 31 (7.8%) | 68 (12.5%) | 163 (8.6%) | |
| XCOPD | < 0.001 | ||||
| Â Â Â No | 907 (95.0%) | 282 (71.0%) | 466 (85.8%) | 1655 (87.3%) | |
| Â Â Â Yes | 48 (5.0%) | 115 (29.0%) | 77 (14.2%) | 240 (12.7%) |
1.1.2 Charachtiristic Analysis
##
## Link between the cluster variable and the categorical variables (chi-square test)
## =================================================================================
## p.value df
## education 8.466764e-38 4
## dyspenea 1.932607e-36 2
## XCOPD 1.264183e-32 2
## Chronic_productive_cough 1.305565e-29 2
## familial_allergy 6.570778e-21 2
## smoking_status 3.436400e-18 4
## Cough 6.584675e-16 2
## Recurrent_wheeze 1.171835e-15 2
## spt_any 1.612689e-15 2
## Emergency_last_year 4.644970e-14 2
## smoking_exposure_at_work 5.133708e-13 2
## Hosptalization_last_year 3.977898e-10 2
## gina_control 3.153103e-08 4
## Ever_rhinitis 3.773596e-06 2
## urbanization_level 4.537210e-06 2
## smoking_exposure_at_home 3.248683e-05 2
## severe_asthma 7.987037e-05 2
## emotion_triggered_asthma 4.703511e-04 2
## Breathlessness 6.653636e-04 2
## gina_steps 2.735099e-03 6
## nasal_plyposis 3.517550e-03 2
## weather_triggered_asthma 6.854829e-03 2
## infection_triggered_asthma 3.331741e-02 2
## exertion_triggered_asthma 3.446631e-02 2
##
## Description of each cluster by the categories
## =============================================
## $`0`
## Cla/Mod Mod/Cla Global p.value
## dyspenea=No 57.01754 88.481675 78.205805 1.751628e-28
## Chronic_productive_cough=No 56.91995 87.853403 77.783641 5.338179e-27
## XCOPD=No 54.80363 94.973822 87.335092 4.287884e-25
## smoking_status=never smoker 59.28086 63.874346 54.300792 2.912917e-17
## familial_allergy=Yes 59.74166 58.115183 49.023747 1.308631e-15
## spt_any=Yes 56.73077 74.136126 65.857520 1.620572e-14
## education=primary 59.34066 56.544503 48.021108 6.559736e-14
## Cough=No 56.32458 74.136126 66.332454 3.886131e-13
## Recurrent_wheeze=No 54.72335 84.921466 78.205805 7.587274e-13
## Emergency_last_year=No 53.80743 89.528796 83.852243 9.674903e-12
## smoking_exposure_at_work=No 56.65796 68.167539 60.633245 1.253808e-11
## Hosptalization_last_year=No 51.77384 97.801047 95.197889 5.416356e-08
## gina_control=controlled 57.60112 43.246073 37.836412 9.794056e-07
## Ever_rhinitis=No 58.30565 36.753927 31.767810 2.582616e-06
## severe_asthma=No 52.58186 87.434555 83.799472 1.468575e-05
## smoking_exposure_at_home=No 56.74548 42.722513 37.941953 1.541434e-05
## Breathlessness=No 56.47249 36.544503 32.612137 2.333367e-04
## urbanization_level=Yes 54.67547 52.041885 47.968338 3.490854e-04
## nasal_plyposis=No 53.77446 60.418848 56.622691 7.828313e-04
## emotion_triggered_asthma=No 51.44342 93.298429 91.398417 2.959205e-03
## weather_triggered_asthma=No 52.48062 70.890052 68.073879 8.092322e-03
## gina_steps=step3 63.54167 6.387435 5.065963 8.206922e-03
## weather_triggered_asthma=Yes 45.95041 29.109948 31.926121 8.092322e-03
## gina_steps=step4 or 5 40.22346 7.539267 9.445910 4.259017e-03
## emotion_triggered_asthma=Yes 39.26380 6.701571 8.601583 2.959205e-03
## nasal_plyposis=Yes 45.98540 39.581152 43.377309 7.828313e-04
## urbanization_level=No 46.45030 47.958115 52.031662 3.490854e-04
## Breathlessness=Yes 47.45497 63.455497 67.387863 2.333367e-04
## smoking_exposure_at_home=Yes 46.51361 57.277487 62.058047 1.541434e-05
## severe_asthma=Yes 39.08795 12.565445 16.200528 1.468575e-05
## smoking_status=current smoker 34.13174 5.968586 8.812665 9.924599e-06
## Ever_rhinitis=Yes 46.71307 63.246073 68.232190 2.582616e-06
## gina_control=uncontrolled 35.66434 10.680628 15.092348 5.762783e-08
## Hosptalization_last_year=Yes 23.07692 2.198953 4.802111 5.416356e-08
## smoking_status=former smokers 41.20172 30.157068 36.886544 9.104283e-10
## smoking_exposure_at_work=Yes 40.75067 31.832461 39.366755 1.253808e-11
## Emergency_last_year=Yes 32.67974 10.471204 16.147757 9.674903e-12
## Recurrent_wheeze=Yes 34.86683 15.078534 21.794195 7.587274e-13
## Cough=Yes 38.71473 25.863874 33.667546 3.886131e-13
## spt_any=No 38.17620 25.863874 34.142480 1.620572e-14
## familial_allergy=No 41.40787 41.884817 50.976253 1.308631e-15
## XCOPD=Yes 20.00000 5.026178 12.664908 4.287884e-25
## education=tertiary 18.64407 4.607330 12.453826 6.580159e-27
## Chronic_productive_cough=Yes 27.55344 12.146597 22.216359 5.338179e-27
## dyspenea=Yes 26.63438 11.518325 21.794195 1.751628e-28
## v.test
## dyspenea=No 11.070122
## Chronic_productive_cough=No 10.759634
## XCOPD=No 10.347671
## smoking_status=never smoker 8.450004
## familial_allergy=Yes 7.993780
## spt_any=Yes 7.677631
## education=primary 7.496394
## Cough=No 7.259469
## Recurrent_wheeze=No 7.168412
## Emergency_last_year=No 6.811258
## smoking_exposure_at_work=No 6.773872
## Hosptalization_last_year=No 5.437071
## gina_control=controlled 4.895732
## Ever_rhinitis=No 4.701497
## severe_asthma=No 4.333350
## smoking_exposure_at_home=No 4.322683
## Breathlessness=No 3.679888
## urbanization_level=Yes 3.575855
## nasal_plyposis=No 3.358795
## emotion_triggered_asthma=No 2.971944
## weather_triggered_asthma=No 2.648193
## gina_steps=step3 2.643436
## weather_triggered_asthma=Yes -2.648193
## gina_steps=step4 or 5 -2.858312
## emotion_triggered_asthma=Yes -2.971944
## nasal_plyposis=Yes -3.358795
## urbanization_level=No -3.575855
## Breathlessness=Yes -3.679888
## smoking_exposure_at_home=Yes -4.322683
## severe_asthma=Yes -4.333350
## smoking_status=current smoker -4.418810
## Ever_rhinitis=Yes -4.701497
## gina_control=uncontrolled -5.426010
## Hosptalization_last_year=Yes -5.437071
## smoking_status=former smokers -6.124370
## smoking_exposure_at_work=Yes -6.773872
## Emergency_last_year=Yes -6.811258
## Recurrent_wheeze=Yes -7.168412
## Cough=Yes -7.259469
## spt_any=No -7.677631
## familial_allergy=No -7.993780
## XCOPD=Yes -10.347671
## education=tertiary -10.740340
## Chronic_productive_cough=Yes -10.759634
## dyspenea=Yes -11.070122
##
## $`1`
## Cla/Mod Mod/Cla Global p.value
## dyspenea=Yes 41.16223 42.821159 21.794195 3.899512e-27
## education=tertiary 50.00000 29.722922 12.453826 8.601147e-27
## XCOPD=Yes 47.91667 28.967254 12.664908 6.489711e-24
## Chronic_productive_cough=Yes 37.29216 39.546599 22.216359 5.662958e-19
## familial_allergy=No 28.98551 70.528967 50.976253 7.808303e-19
## Cough=Yes 30.56426 49.118388 33.667546 7.034506e-13
## Recurrent_wheeze=Yes 33.89831 35.264484 21.794195 2.363681e-12
## Emergency_last_year=Yes 35.62092 27.455919 16.147757 6.507180e-11
## spt_any=No 29.52087 48.110831 34.142480 9.135132e-11
## smoking_exposure_at_work=Yes 28.28418 53.148615 39.366755 3.997970e-10
## smoking_status=former smokers 28.46924 50.125945 36.886544 1.326465e-09
## Hosptalization_last_year=Yes 46.15385 10.579345 4.802111 3.657191e-08
## smoking_exposure_at_home=Yes 23.46939 69.521411 62.058047 5.071492e-04
## gina_control=uncontrolled 27.62238 19.899244 15.092348 3.414147e-03
## smoking_status=current smoker 29.34132 12.342569 8.812665 7.150165e-03
## severe_asthma=Yes 26.38436 20.403023 16.200528 1.239246e-02
## Drug_induced_dyspnea=Yes 29.62963 8.060453 5.699208 2.805763e-02
## allergen_triggered_asthma=No 22.22222 75.062972 70.765172 3.295889e-02
## household_damage=No 21.66566 90.428212 87.440633 3.978242e-02
## gina_steps=step 1 or 2 16.91395 14.357683 17.783641 4.201864e-02
## household_damage=Yes 15.96639 9.571788 12.559367 3.978242e-02
## allergen_triggered_asthma=Yes 17.87004 24.937028 29.234828 3.295889e-02
## Drug_induced_dyspnea=No 20.42529 91.939547 94.300792 2.805763e-02
## severe_asthma=No 19.89924 79.596977 83.799472 1.239246e-02
## gina_control=controlled 17.15481 30.982368 37.836412 1.415909e-03
## smoking_exposure_at_home=No 16.82893 30.478589 37.941953 5.071492e-04
## Hosptalization_last_year=No 19.67849 89.420655 95.197889 3.657191e-08
## smoking_exposure_at_work=No 16.18799 46.851385 60.633245 3.997970e-10
## spt_any=Yes 16.50641 51.889169 65.857520 9.135132e-11
## Emergency_last_year=No 18.12461 72.544081 83.852243 6.507180e-11
## education=primary 14.28571 32.745592 48.021108 5.004501e-12
## Recurrent_wheeze=No 17.34143 64.735516 78.205805 2.363681e-12
## Cough=No 16.07001 50.881612 66.332454 7.034506e-13
## smoking_status=never smoker 14.48008 37.531486 54.300792 4.846427e-14
## familial_allergy=Yes 12.59419 29.471033 49.023747 7.808303e-19
## Chronic_productive_cough=No 16.28223 60.453401 77.783641 5.662958e-19
## XCOPD=No 17.03927 71.032746 87.335092 6.489711e-24
## dyspenea=No 15.31714 57.178841 78.205805 3.899512e-27
## v.test
## dyspenea=Yes 10.788536
## education=tertiary 10.715585
## XCOPD=Yes 10.084192
## Chronic_productive_cough=Yes 8.898455
## familial_allergy=No 8.862724
## Cough=Yes 7.178763
## Recurrent_wheeze=Yes 7.011149
## Emergency_last_year=Yes 6.531598
## spt_any=No 6.480612
## smoking_exposure_at_work=Yes 6.254107
## smoking_status=former smokers 6.064158
## Hosptalization_last_year=Yes 5.506654
## smoking_exposure_at_home=Yes 3.476952
## gina_control=uncontrolled 2.927759
## smoking_status=current smoker 2.689768
## severe_asthma=Yes 2.500767
## Drug_induced_dyspnea=Yes 2.196480
## allergen_triggered_asthma=No 2.132584
## household_damage=No 2.056001
## gina_steps=step 1 or 2 -2.033336
## household_damage=Yes -2.056001
## allergen_triggered_asthma=Yes -2.132584
## Drug_induced_dyspnea=No -2.196480
## severe_asthma=No -2.500767
## gina_control=controlled -3.191388
## smoking_exposure_at_home=No -3.476952
## Hosptalization_last_year=No -5.506654
## smoking_exposure_at_work=No -6.254107
## spt_any=Yes -6.480612
## Emergency_last_year=No -6.531598
## education=primary -6.905449
## Recurrent_wheeze=No -7.011149
## Cough=No -7.178763
## smoking_status=never smoker -7.535990
## familial_allergy=Yes -8.862724
## Chronic_productive_cough=No -8.898455
## XCOPD=No -10.084192
## dyspenea=No -10.788536
##
## $`2`
## Cla/Mod Mod/Cla Global p.value
## urbanization_level=No 33.56998 60.957643 52.031662 7.840282e-07
## Ever_rhinitis=Yes 31.70920 75.506446 68.232190 1.274574e-05
## emotion_triggered_asthma=Yes 41.71779 12.523020 8.601583 1.912227e-04
## Chronic_productive_cough=Yes 35.15439 27.255985 22.216359 9.794868e-04
## gina_control=uncontrolled 36.71329 19.337017 15.092348 1.345849e-03
## Breathlessness=Yes 30.93187 72.744015 67.387863 1.498340e-03
## weather_triggered_asthma=Yes 33.22314 37.016575 31.926121 2.804268e-03
## infection_triggered_asthma=Yes 30.82251 65.561694 60.949868 8.915430e-03
## spt_any=No 32.30294 38.489871 34.142480 1.192917e-02
## severe_asthma=Yes 34.52769 19.521179 16.200528 1.426313e-02
## exertion_triggered_asthma=Yes 30.58130 66.850829 62.638522 1.599374e-02
## smoking_status=current smoker 36.52695 11.233886 8.812665 2.104577e-02
## nasal_plyposis=Yes 31.14355 47.145488 43.377309 3.642048e-02
## gina_steps=step3 19.79167 3.499079 5.065963 4.456487e-02
## nasal_plyposis=No 26.74744 52.854512 56.622691 3.642048e-02
## education=primary 26.37363 44.198895 48.021108 3.490587e-02
## exertion_triggered_asthma=No 25.42373 33.149171 37.361478 1.599374e-02
## severe_asthma=No 27.51889 80.478821 83.799472 1.426313e-02
## spt_any=Yes 26.76282 61.510129 65.857520 1.192917e-02
## smoking_status=never smoker 26.23907 49.723757 54.300792 1.142906e-02
## gina_control=controlled 25.24407 33.333333 37.836412 1.018202e-02
## infection_triggered_asthma=No 25.27027 34.438306 39.050132 8.915430e-03
## weather_triggered_asthma=No 26.51163 62.983425 68.073879 2.804268e-03
## Breathlessness=No 23.94822 27.255985 32.612137 1.498340e-03
## Chronic_productive_cough=No 26.79783 72.744015 77.783641 9.794868e-04
## emotion_triggered_asthma=No 27.42494 87.476980 91.398417 1.912227e-04
## Ever_rhinitis=No 22.09302 24.493554 31.767810 1.274574e-05
## urbanization_level=Yes 23.32233 39.042357 47.968338 7.840282e-07
## v.test
## urbanization_level=No 4.939302
## Ever_rhinitis=Yes 4.364425
## emotion_triggered_asthma=Yes 3.730338
## Chronic_productive_cough=Yes 3.296354
## gina_control=uncontrolled 3.206020
## Breathlessness=Yes 3.175005
## weather_triggered_asthma=Yes 2.988417
## infection_triggered_asthma=Yes 2.615280
## spt_any=No 2.514233
## severe_asthma=Yes 2.450567
## exertion_triggered_asthma=Yes 2.409058
## smoking_status=current smoker 2.307162
## nasal_plyposis=Yes 2.092202
## gina_steps=step3 -2.008739
## nasal_plyposis=No -2.092202
## education=primary -2.109449
## exertion_triggered_asthma=No -2.409058
## severe_asthma=No -2.450567
## spt_any=Yes -2.514233
## smoking_status=never smoker -2.529299
## gina_control=controlled -2.569586
## infection_triggered_asthma=No -2.615280
## weather_triggered_asthma=No -2.988417
## Breathlessness=No -3.175005
## Chronic_productive_cough=No -3.296354
## emotion_triggered_asthma=No -3.730338
## Ever_rhinitis=No -4.364425
## urbanization_level=Yes -4.939302
##
##
## Link between the cluster variable and the quantitative variables
## ================================================================
## Eta2 P-value
## Basophiles 0.889590036 0.000000e+00
## Age 0.295123189 2.065900e-144
## pack_years 0.240751915 6.966029e-114
## tlco 0.209958064 1.503269e-97
## kco 0.188763354 1.131338e-86
## onset_age_asthma 0.157322700 4.737894e-71
## FEV1_FVC_ratio_post 0.119194115 7.189130e-53
## Monocytes 0.070253255 1.182972e-30
## Neutrophiles 0.061543629 8.011729e-27
## Eosinophiles 0.060025777 3.695583e-26
## BMI 0.059671496 5.278404e-26
## pd20 0.029827432 3.623642e-13
## Lymphocytes 0.025257488 3.089247e-11
## Reversibility 0.020671683 2.619289e-09
## FeNO 0.009222953 1.560401e-04
##
## Description of each cluster by quantitative variables
## =====================================================
## $`0`
## v.test Mean in category Overall mean sd in category
## tlco 15.201883 1.064360e+02 1.001420e+02 1.350624e+01
## kco 13.255510 1.036379e+02 9.897243e+01 1.233246e+01
## FEV1_FVC_ratio_post 12.774437 7.979581e-01 7.699727e-01 7.025519e-02
## FeNO -3.110098 2.392251e+01 2.550929e+01 1.929250e+01
## Lymphocytes -4.388328 1.914471e+00 1.982802e+00 5.556288e-01
## pd20 -5.482254 1.658220e+03 1.952471e+03 2.669253e+03
## Reversibility -5.961762 6.289978e+00 7.333086e+00 6.390588e+00
## Eosinophiles -8.832654 1.864607e-01 2.196359e-01 1.302886e-01
## BMI -9.019472 2.605850e+01 2.706171e+01 4.345589e+00
## Neutrophiles -10.796400 3.515832e+00 3.856132e+00 1.141669e+00
## Monocytes -11.534064 3.858429e-01 4.264011e-01 1.247414e-01
## onset_age_asthma -14.409511 1.588272e+01 2.149024e+01 1.231178e+01
## pack_years -17.250577 6.389570e+00 1.194451e+01 6.938524e+00
## Age -19.673801 4.267120e+01 4.971821e+01 1.299645e+01
## Basophiles -27.158675 2.680628e-03 3.133509e-02 8.998987e-03
## Overall sd p.value
## tlco 1.816168e+01 3.435997e-52
## kco 1.543910e+01 4.192587e-40
## FEV1_FVC_ratio_post 9.609862e-02 2.277887e-37
## FeNO 2.238045e+01 1.870253e-03
## Lymphocytes 6.830395e-01 1.142254e-05
## pd20 2.354436e+03 4.199404e-08
## Reversibility 7.675073e+00 2.495328e-09
## Eosinophiles 1.647591e-01 1.022212e-18
## BMI 4.879071e+00 1.889982e-19
## Neutrophiles 1.382643e+00 3.579666e-27
## Monocytes 1.542493e-01 8.884861e-31
## onset_age_asthma 1.707061e+01 4.508884e-47
## pack_years 1.412548e+01 1.107871e-66
## Age 1.571245e+01 3.616301e-86
## Basophiles 4.628193e-02 1.999964e-162
##
## $`1`
## v.test Mean in category Overall mean sd in category
## Age 21.416598 6.473804e+01 4.971821e+01 9.971591e+00
## pack_years 19.710009 2.437135e+01 1.194451e+01 1.874286e+01
## onset_age_asthma 15.601791 3.337783e+01 2.149024e+01 1.891898e+01
## BMI 9.490606 2.912852e+01 2.706171e+01 5.363724e+00
## pd20 7.240108 2.713327e+03 1.952471e+03 1.942051e+03
## Monocytes 5.849664 4.666751e-01 4.264011e-01 1.945945e-01
## Neutrophiles 5.634040 4.203829e+00 3.856132e+00 1.627679e+00
## Reversibility 4.717609 8.949212e+00 7.333086e+00 1.026050e+01
## Lymphocytes -2.292948 1.912897e+00 1.982802e+00 7.568018e-01
## Basophiles -12.217897 6.095718e-03 3.133509e-02 1.971129e-02
## FEV1_FVC_ratio_post -13.390300 7.125375e-01 7.699727e-01 1.169122e-01
## kco -18.404553 8.628955e+01 9.897243e+01 1.468720e+01
## tlco -18.920649 8.480418e+01 1.001420e+02 1.481884e+01
## Overall sd p.value
## Age 1.571245e+01 9.357834e-102
## pack_years 1.412548e+01 1.769361e-86
## onset_age_asthma 1.707061e+01 7.078042e-55
## BMI 4.879071e+00 2.296956e-21
## pd20 2.354436e+03 4.483265e-13
## Monocytes 1.542493e-01 4.925668e-09
## Neutrophiles 1.382643e+00 1.760359e-08
## Reversibility 7.675073e+00 2.386328e-06
## Lymphocytes 6.830395e-01 2.185102e-02
## Basophiles 4.628193e-02 2.494540e-34
## FEV1_FVC_ratio_post 9.609862e-02 6.890208e-41
## kco 1.543910e+01 1.207763e-75
## tlco 1.816168e+01 7.709915e-80
##
## $`2`
## v.test Mean in category Overall mean sd in category
## Basophiles 41.028740 0.1001842 0.03133509 0.01997151
## Eosinophiles 10.237438 0.2807919 0.21963588 0.18558037
## Monocytes 7.489445 0.4682873 0.42640106 0.14882293
## Lymphocytes 6.916371 2.1540884 1.98280211 0.79078105
## Neutrophiles 6.867805 4.2004236 3.85613193 1.42535550
## FeNO 4.134843 28.8645488 25.50928760 25.80411174
## Age 2.479484 51.1307551 49.71820580 15.41254161
## Reversibility 2.346480 7.9860632 7.33308613 7.24773273
## FEV1_FVC_ratio_post -2.074162 0.7627457 0.76997268 0.09855523
## Overall sd p.value
## Basophiles 0.04628193 0.000000e+00
## Eosinophiles 0.16475912 1.347582e-24
## Monocytes 0.15424932 6.916532e-14
## Lymphocytes 0.68303954 4.633588e-12
## Neutrophiles 1.38264302 6.519710e-12
## FeNO 22.38045429 3.551978e-05
## Age 15.71244775 1.315726e-02
## Reversibility 7.67507328 1.895166e-02
## FEV1_FVC_ratio_post 0.09609862 3.806425e-021.1.3 Radar Plots
1.1.4 parallel box plots
1.1.5 parallel coordinate plot
1.2 Deep Empedding Clustering on the asthmatic encoded data 3 clusters
1.2.1 Summary table
# results_Kam <- get_ClusterResults(OriginalData = my_imp_data, Labels = kamRes$finalMemb)
table_result <- tableby(clusters ~ ., data = as.list(results_cluster_data))
summary(table_result, title = "Charachtaristcs of Clusters") | 0 (N=559) | 1 (N=656) | 2 (N=680) | Total (N=1895) | p value | |
|---|---|---|---|---|---|
| Age | < 0.001 | ||||
| Â Â Â Mean (SD) | 65.052 (9.199) | 42.290 (13.678) | 44.279 (12.747) | 49.718 (15.717) | |
| Â Â Â Range | 28.000 - 86.000 | 17.000 - 97.000 | 18.000 - 78.000 | 17.000 - 97.000 | |
| Gender | 0.068 | ||||
| Â Â Â No | 221 (39.5%) | 287 (43.8%) | 256 (37.6%) | 764 (40.3%) | |
| Â Â Â Yes | 338 (60.5%) | 369 (56.2%) | 424 (62.4%) | 1131 (59.7%) | |
| BMI | < 0.001 | ||||
| Â Â Â Mean (SD) | 28.041 (4.807) | 25.666 (4.263) | 27.602 (5.191) | 27.062 (4.880) | |
| Â Â Â Range | 17.603 - 48.870 | 17.029 - 46.094 | 17.509 - 50.058 | 17.029 - 50.058 | |
| age at asthma onset as numeeric variable | < 0.001 | ||||
| Â Â Â Mean (SD) | 35.342 (18.937) | 14.855 (11.873) | 16.504 (12.538) | 21.490 (17.075) | |
| Â Â Â Range | 1.000 - 72.000 | -1.000 - 62.000 | -1.000 - 68.000 | -1.000 - 72.000 | |
| Cough | < 0.001 | ||||
| Â Â Â No | 291 (52.1%) | 524 (79.9%) | 442 (65.0%) | 1257 (66.3%) | |
| Â Â Â Yes | 268 (47.9%) | 132 (20.1%) | 238 (35.0%) | 638 (33.7%) | |
| Breathlessness | < 0.001 | ||||
| Â Â Â No | 174 (31.1%) | 344 (52.4%) | 100 (14.7%) | 618 (32.6%) | |
| Â Â Â Yes | 385 (68.9%) | 312 (47.6%) | 580 (85.3%) | 1277 (67.4%) | |
| Recurrent_wheeze | < 0.001 | ||||
| Â Â Â No | 381 (68.2%) | 595 (90.7%) | 506 (74.4%) | 1482 (78.2%) | |
| Â Â Â Yes | 178 (31.8%) | 61 (9.3%) | 174 (25.6%) | 413 (21.8%) | |
| dyspenea | < 0.001 | ||||
| Â Â Â No | 325 (58.1%) | 596 (90.9%) | 561 (82.5%) | 1482 (78.2%) | |
| Â Â Â Yes | 234 (41.9%) | 60 (9.1%) | 119 (17.5%) | 413 (21.8%) | |
| Chronic_productive_cough | < 0.001 | ||||
| Â Â Â No | 348 (62.3%) | 592 (90.2%) | 534 (78.5%) | 1474 (77.8%) | |
| Â Â Â Yes | 211 (37.7%) | 64 (9.8%) | 146 (21.5%) | 421 (22.2%) | |
| FEV1_FVC_ratio_post | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.710 (0.119) | 0.806 (0.066) | 0.784 (0.075) | 0.770 (0.096) | |
| Â Â Â Range | 0.230 - 1.590 | 0.557 - 1.009 | 0.524 - 1.000 | 0.230 - 1.590 | |
| Reversibility | < 0.001 | ||||
| Â Â Â Mean (SD) | 9.400 (9.882) | 4.687 (4.788) | 8.187 (7.143) | 7.333 (7.677) | |
| Â Â Â Range | -12.121 - 77.242 | -26.774 - 35.757 | -9.470 - 53.704 | -26.774 - 77.242 | |
| pd20 | < 0.001 | ||||
| Â Â Â Mean (SD) | 2870.432 (1995.504) | 1707.770 (2894.928) | 1433.918 (1758.732) | 1952.471 (2355.058) | |
| Â Â Â Range | 0.059 - 13923.750 | -26261.250 - 38775.000 | -2562.590 - 19387.500 | -26261.250 - 38775.000 | |
| tlco | < 0.001 | ||||
| Â Â Â Mean (SD) | 84.785 (14.530) | 104.451 (12.595) | 108.610 (17.611) | 100.142 (18.166) | |
| Â Â Â Range | 44.453 - 136.837 | 63.818 - 148.214 | 68.403 - 389.709 | 44.453 - 389.709 | |
| kco | < 0.001 | ||||
| Â Â Â Mean (SD) | 86.714 (14.512) | 101.101 (11.865) | 106.997 (12.798) | 98.972 (15.443) | |
| Â Â Â Range | 40.972 - 139.418 | 69.866 - 142.603 | 60.955 - 149.720 | 40.972 - 149.720 | |
| FeNO | < 0.001 | ||||
| Â Â Â Mean (SD) | 23.508 (21.201) | 19.964 (12.262) | 32.504 (28.311) | 25.509 (22.386) | |
| Â Â Â Range | 3.600 - 168.000 | 3.300 - 96.000 | 5.000 - 226.000 | 3.300 - 226.000 | |
| Eosinophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.242 (0.189) | 0.166 (0.107) | 0.253 (0.176) | 0.220 (0.165) | |
| Â Â Â Range | 0.000 - 2.300 | 0.000 - 0.900 | 0.000 - 1.200 | 0.000 - 2.300 | |
| Neutrophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 4.362 (1.580) | 3.410 (1.074) | 3.871 (1.330) | 3.856 (1.383) | |
| Â Â Â Range | 1.300 - 12.500 | 1.300 - 7.200 | 1.000 - 10.600 | 1.000 - 12.500 | |
| Lymphocyties | < 0.001 | ||||
| Â Â Â Mean (SD) | 2.075 (0.909) | 1.906 (0.544) | 1.981 (0.570) | 1.983 (0.683) | |
| Â Â Â Range | 0.300 - 11.200 | 0.600 - 4.100 | 0.600 - 5.000 | 0.300 - 11.200 | |
| Monocytes | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.475 (0.185) | 0.379 (0.123) | 0.431 (0.140) | 0.426 (0.154) | |
| Â Â Â Range | 0.200 - 2.400 | 0.200 - 1.000 | 0.200 - 1.100 | 0.200 - 2.400 | |
| Basophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.039 (0.050) | 0.015 (0.034) | 0.041 (0.050) | 0.031 (0.046) | |
| Â Â Â Range | 0.000 - 0.300 | 0.000 - 0.190 | 0.000 - 0.200 | 0.000 - 0.300 | |
| spt_any | < 0.001 | ||||
| Â Â Â No | 319 (57.1%) | 171 (26.1%) | 157 (23.1%) | 647 (34.1%) | |
| Â Â Â Yes | 240 (42.9%) | 485 (73.9%) | 523 (76.9%) | 1248 (65.9%) | |
| familial_allergy | < 0.001 | ||||
| Â Â Â No | 386 (69.1%) | 325 (49.5%) | 255 (37.5%) | 966 (51.0%) | |
| Â Â Â Yes | 173 (30.9%) | 331 (50.5%) | 425 (62.5%) | 929 (49.0%) | |
| Drug_induced_dyspnea | 0.299 | ||||
| Â Â Â No | 521 (93.2%) | 625 (95.3%) | 641 (94.3%) | 1787 (94.3%) | |
| Â Â Â Yes | 38 (6.8%) | 31 (4.7%) | 39 (5.7%) | 108 (5.7%) | |
| nasal_plyposis | 0.001 | ||||
| Â Â Â No | 281 (50.3%) | 384 (58.5%) | 408 (60.0%) | 1073 (56.6%) | |
| Â Â Â Yes | 278 (49.7%) | 272 (41.5%) | 272 (40.0%) | 822 (43.4%) | |
| Ever_rhinitis | < 0.001 | ||||
| Â Â Â No | 127 (22.7%) | 257 (39.2%) | 218 (32.1%) | 602 (31.8%) | |
| Â Â Â Yes | 432 (77.3%) | 399 (60.8%) | 462 (67.9%) | 1293 (68.2%) | |
| gina_steps | < 0.001 | ||||
| Â Â Â onlys saba or non users | 361 (64.6%) | 555 (84.6%) | 367 (54.0%) | 1283 (67.7%) | |
| Â Â Â step 1 or 2 | 88 (15.7%) | 75 (11.4%) | 174 (25.6%) | 337 (17.8%) | |
| Â Â Â step3 | 25 (4.5%) | 17 (2.6%) | 54 (7.9%) | 96 (5.1%) | |
| Â Â Â step4 or 5 | 85 (15.2%) | 9 (1.4%) | 85 (12.5%) | 179 (9.4%) | |
| Hosptalization_last_year | < 0.001 | ||||
| Â Â Â No | 498 (89.1%) | 644 (98.2%) | 662 (97.4%) | 1804 (95.2%) | |
| Â Â Â Yes | 61 (10.9%) | 12 (1.8%) | 18 (2.6%) | 91 (4.8%) | |
| Emergency_last_year | < 0.001 | ||||
| Â Â Â No | 409 (73.2%) | 599 (91.3%) | 581 (85.4%) | 1589 (83.9%) | |
| Â Â Â Yes | 150 (26.8%) | 57 (8.7%) | 99 (14.6%) | 306 (16.1%) | |
| severe_asthma | < 0.001 | ||||
| Â Â Â No | 424 (75.8%) | 625 (95.3%) | 539 (79.3%) | 1588 (83.8%) | |
| Â Â Â Yes | 135 (24.2%) | 31 (4.7%) | 141 (20.7%) | 307 (16.2%) | |
| gina_control | < 0.001 | ||||
| Â Â Â controlled | 158 (28.3%) | 342 (52.1%) | 217 (31.9%) | 717 (37.8%) | |
| Â Â Â partially controlled | 287 (51.3%) | 261 (39.8%) | 344 (50.6%) | 892 (47.1%) | |
| Â Â Â uncontrolled | 114 (20.4%) | 53 (8.1%) | 119 (17.5%) | 286 (15.1%) | |
| education | < 0.001 | ||||
| Â Â Â primary | 181 (32.4%) | 361 (55.0%) | 368 (54.1%) | 910 (48.0%) | |
| Â Â Â secondary | 214 (38.3%) | 260 (39.6%) | 275 (40.4%) | 749 (39.5%) | |
| Â Â Â tertiary | 164 (29.3%) | 35 (5.3%) | 37 (5.4%) | 236 (12.5%) | |
| urbanization_level | < 0.001 | ||||
| Â Â Â No | 324 (58.0%) | 280 (42.7%) | 382 (56.2%) | 986 (52.0%) | |
| Â Â Â Yes | 235 (42.0%) | 376 (57.3%) | 298 (43.8%) | 909 (48.0%) | |
| smoking_status | < 0.001 | ||||
| Â Â Â never smoker | 173 (30.9%) | 434 (66.2%) | 422 (62.1%) | 1029 (54.3%) | |
| Â Â Â former smokers | 295 (52.8%) | 189 (28.8%) | 215 (31.6%) | 699 (36.9%) | |
| Â Â Â current smoker | 91 (16.3%) | 33 (5.0%) | 43 (6.3%) | 167 (8.8%) | |
| pack_years | < 0.001 | ||||
| Â Â Â Mean (SD) | 25.409 (18.092) | 5.755 (6.031) | 6.847 (6.364) | 11.945 (14.129) | |
| Â Â Â Range | 0.000 - 112.500 | 0.000 - 33.750 | 0.000 - 36.000 | 0.000 - 112.500 | |
| smoking_exposure_at_home | < 0.001 | ||||
| Â Â Â No | 132 (23.6%) | 310 (47.3%) | 277 (40.7%) | 719 (37.9%) | |
| Â Â Â Yes | 427 (76.4%) | 346 (52.7%) | 403 (59.3%) | 1176 (62.1%) | |
| smoking_exposure_at_work | < 0.001 | ||||
| Â Â Â No | 230 (41.1%) | 474 (72.3%) | 445 (65.4%) | 1149 (60.6%) | |
| Â Â Â Yes | 329 (58.9%) | 182 (27.7%) | 235 (34.6%) | 746 (39.4%) | |
| household_damage | 0.003 | ||||
| Â Â Â No | 510 (91.2%) | 557 (84.9%) | 590 (86.8%) | 1657 (87.4%) | |
| Â Â Â Yes | 49 (8.8%) | 99 (15.1%) | 90 (13.2%) | 238 (12.6%) | |
| exertion_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 213 (38.1%) | 420 (64.0%) | 75 (11.0%) | 708 (37.4%) | |
| Â Â Â Yes | 346 (61.9%) | 236 (36.0%) | 605 (89.0%) | 1187 (62.6%) | |
| infection_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 207 (37.0%) | 442 (67.4%) | 91 (13.4%) | 740 (39.1%) | |
| Â Â Â Yes | 352 (63.0%) | 214 (32.6%) | 589 (86.6%) | 1155 (60.9%) | |
| allergen_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 432 (77.3%) | 560 (85.4%) | 349 (51.3%) | 1341 (70.8%) | |
| Â Â Â Yes | 127 (22.7%) | 96 (14.6%) | 331 (48.7%) | 554 (29.2%) | |
| irritant_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 485 (86.8%) | 624 (95.1%) | 503 (74.0%) | 1612 (85.1%) | |
| Â Â Â Yes | 74 (13.2%) | 32 (4.9%) | 177 (26.0%) | 283 (14.9%) | |
| weather_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 394 (70.5%) | 604 (92.1%) | 292 (42.9%) | 1290 (68.1%) | |
| Â Â Â Yes | 165 (29.5%) | 52 (7.9%) | 388 (57.1%) | 605 (31.9%) | |
| emotion_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 510 (91.2%) | 652 (99.4%) | 570 (83.8%) | 1732 (91.4%) | |
| Â Â Â Yes | 49 (8.8%) | 4 (0.6%) | 110 (16.2%) | 163 (8.6%) | |
| XCOPD | < 0.001 | ||||
| Â Â Â No | 387 (69.2%) | 630 (96.0%) | 638 (93.8%) | 1655 (87.3%) | |
| Â Â Â Yes | 172 (30.8%) | 26 (4.0%) | 42 (6.2%) | 240 (12.7%) |
1.2.2 Charachtiristic Analysis
##
## Link between the cluster variable and the categorical variables (chi-square test)
## =================================================================================
## p.value df
## infection_triggered_asthma 7.770721e-90 2
## exertion_triggered_asthma 8.920707e-88 2
## weather_triggered_asthma 1.021583e-81 2
## XCOPD 4.557274e-52 2
## Breathlessness 7.153113e-48 2
## education 5.927730e-47 4
## allergen_triggered_asthma 7.120301e-45 2
## dyspenea 2.275136e-44 2
## spt_any 2.990235e-41 2
## smoking_status 3.120667e-39 4
## gina_steps 9.319070e-36 6
## Chronic_productive_cough 1.635677e-30 2
## smoking_exposure_at_work 1.562552e-29 2
## familial_allergy 1.914809e-27 2
## irritant_triggered_asthma 1.193890e-26 2
## Cough 1.267104e-23 2
## emotion_triggered_asthma 4.427578e-23 2
## severe_asthma 1.979200e-22 2
## Recurrent_wheeze 3.258712e-22 2
## gina_control 5.926539e-21 4
## Emergency_last_year 4.317374e-17 2
## smoking_exposure_at_home 4.769782e-17 2
## Hosptalization_last_year 6.802227e-15 2
## Ever_rhinitis 6.332159e-09 2
## urbanization_level 1.931187e-08 2
## nasal_plyposis 1.277352e-03 2
## household_damage 3.281938e-03 2
##
## Description of each cluster by the categories
## =============================================
## $`0`
## Cla/Mod Mod/Cla Global p.value
## XCOPD=Yes 71.66667 30.769231 12.664908 5.944927e-48
## education=tertiary 69.49153 29.338104 12.453826 1.757778e-42
## spt_any=No 49.30448 57.066190 34.142480 5.661621e-41
## dyspenea=Yes 56.65860 41.860465 21.794195 9.563530e-40
## smoking_exposure_at_work=Yes 44.10188 58.855098 39.366755 7.243320e-29
## familial_allergy=No 39.95859 69.051878 50.976253 9.550156e-25
## Chronic_productive_cough=Yes 50.11876 37.745975 22.216359 2.267578e-24
## smoking_status=former smokers 42.20315 52.772809 36.886544 4.674902e-20
## smoking_exposure_at_home=Yes 36.30952 76.386404 62.058047 2.160771e-17
## Cough=Yes 42.00627 47.942755 33.667546 5.045310e-17
## Emergency_last_year=Yes 49.01961 26.833631 16.147757 3.224529e-15
## Hosptalization_last_year=Yes 67.03297 10.912343 4.802111 3.991604e-14
## smoking_status=current smoker 54.49102 16.279070 8.812665 1.654341e-12
## Recurrent_wheeze=Yes 43.09927 31.842576 21.794195 2.340878e-11
## severe_asthma=Yes 43.97394 24.150268 16.200528 3.743826e-09
## Ever_rhinitis=Yes 33.41067 77.280859 68.232190 2.622019e-08
## gina_steps=step4 or 5 47.48603 15.205725 9.445910 9.880220e-08
## allergen_triggered_asthma=No 32.21477 77.280859 70.765172 4.409344e-05
## gina_control=uncontrolled 39.86014 20.393560 15.092348 4.659714e-05
## nasal_plyposis=Yes 33.81995 49.731664 43.377309 3.203071e-04
## urbanization_level=No 32.86004 57.960644 52.031662 8.284634e-04
## household_damage=No 30.77852 91.234347 87.440633 9.577649e-04
## gina_control=partially controlled 32.17489 51.341682 47.071240 1.617065e-02
## household_damage=Yes 20.58824 8.765653 12.559367 9.577649e-04
## urbanization_level=Yes 25.85259 42.039356 47.968338 8.284634e-04
## nasal_plyposis=No 26.18826 50.268336 56.622691 3.203071e-04
## allergen_triggered_asthma=Yes 22.92419 22.719141 29.234828 4.409344e-05
## Ever_rhinitis=No 21.09635 22.719141 31.767810 2.622019e-08
## gina_control=controlled 22.03626 28.264758 37.836412 1.918175e-08
## severe_asthma=No 26.70025 75.849732 83.799472 3.743826e-09
## Recurrent_wheeze=No 25.70850 68.157424 78.205805 2.340878e-11
## Hosptalization_last_year=No 27.60532 89.087657 95.197889 3.991604e-14
## Emergency_last_year=No 25.73946 73.166369 83.852243 3.224529e-15
## Cough=No 23.15036 52.057245 66.332454 5.045310e-17
## smoking_exposure_at_home=No 18.35883 23.613596 37.941953 2.160771e-17
## education=primary 19.89011 32.379249 48.021108 6.518154e-19
## Chronic_productive_cough=No 23.60923 62.254025 77.783641 2.267578e-24
## familial_allergy=Yes 18.62217 30.948122 49.023747 9.550156e-25
## smoking_exposure_at_work=No 20.01741 41.144902 60.633245 7.243320e-29
## dyspenea=No 21.92982 58.139535 78.205805 9.563530e-40
## smoking_status=never smoker 16.81244 30.948122 54.300792 3.586091e-40
## spt_any=Yes 19.23077 42.933810 65.857520 5.661621e-41
## XCOPD=No 23.38369 69.230769 87.335092 5.944927e-48
## v.test
## XCOPD=Yes 14.548785
## education=tertiary 13.660085
## spt_any=No 13.404878
## dyspenea=Yes 13.193503
## smoking_exposure_at_work=Yes 11.148978
## familial_allergy=No 10.270708
## Chronic_productive_cough=Yes 10.186954
## smoking_status=former smokers 9.171267
## smoking_exposure_at_home=Yes 8.484807
## Cough=Yes 8.385634
## Emergency_last_year=Yes 7.881895
## Hosptalization_last_year=Yes 7.561267
## smoking_status=current smoker 7.060895
## Recurrent_wheeze=Yes 6.683007
## severe_asthma=Yes 5.895132
## Ever_rhinitis=Yes 5.564967
## gina_steps=step4 or 5 5.328913
## allergen_triggered_asthma=No 4.084912
## gina_control=uncontrolled 4.072070
## nasal_plyposis=Yes 3.598298
## urbanization_level=No 3.343106
## household_damage=No 3.302648
## gina_control=partially controlled 2.405041
## household_damage=Yes -3.302648
## urbanization_level=Yes -3.343106
## nasal_plyposis=No -3.598298
## allergen_triggered_asthma=Yes -4.084912
## Ever_rhinitis=No -5.564967
## gina_control=controlled -5.619224
## severe_asthma=No -5.895132
## Recurrent_wheeze=No -6.683007
## Hosptalization_last_year=No -7.561267
## Emergency_last_year=No -7.881895
## Cough=No -8.385634
## smoking_exposure_at_home=No -8.484807
## education=primary -8.882828
## Chronic_productive_cough=No -10.186954
## familial_allergy=Yes -10.270708
## smoking_exposure_at_work=No -11.148978
## dyspenea=No -13.193503
## smoking_status=never smoker -13.267227
## spt_any=Yes -13.404878
## XCOPD=No -14.548785
##
## $`1`
## Cla/Mod Mod/Cla Global p.value
## infection_triggered_asthma=No 59.729730 67.3780488 39.050132 1.007907e-75
## weather_triggered_asthma=No 46.821705 92.0731707 68.073879 1.781301e-68
## exertion_triggered_asthma=No 59.322034 64.0243902 37.361478 6.536117e-68
## Breathlessness=No 55.663430 52.4390244 32.612137 4.705226e-40
## gina_steps=onlys saba or non users 43.257989 84.6036585 67.704485 1.822263e-32
## severe_asthma=No 39.357683 95.2743902 83.799472 1.289689e-26
## allergen_triggered_asthma=No 41.759881 85.3658537 70.765172 5.887110e-26
## emotion_triggered_asthma=No 37.644342 99.3902439 91.398417 6.490237e-26
## dyspenea=No 40.215924 90.8536585 78.205805 1.584008e-24
## Recurrent_wheeze=No 40.148448 90.7012195 78.205805 6.232842e-24
## Chronic_productive_cough=No 40.162822 90.2439024 77.783641 2.072044e-23
## irritant_triggered_asthma=No 38.709677 95.1219512 85.065963 6.887756e-22
## Cough=No 41.686555 79.8780488 66.332454 1.587363e-20
## gina_control=controlled 47.698745 52.1341463 37.836412 1.739316e-20
## XCOPD=No 38.066465 96.0365854 87.335092 3.390370e-19
## smoking_exposure_at_work=No 41.253264 72.2560976 60.633245 2.526618e-14
## smoking_status=never smoker 42.176871 66.1585366 54.300792 3.368020e-14
## Emergency_last_year=No 37.696665 91.3109756 83.852243 2.460880e-11
## smoking_exposure_at_home=No 43.115438 47.2560976 37.941953 1.500440e-09
## urbanization_level=Yes 41.364136 57.3170732 47.968338 3.098523e-09
## spt_any=Yes 38.862179 73.9329268 65.857520 5.082243e-08
## Ever_rhinitis=No 42.691030 39.1768293 31.767810 5.787715e-07
## Hosptalization_last_year=No 35.698448 98.1707317 95.197889 2.694266e-06
## education=primary 39.670330 55.0304878 48.021108 8.981966e-06
## household_damage=Yes 41.596639 15.0914634 12.559367 1.679959e-02
## Gender=No 37.565445 43.7500000 40.316623 2.702428e-02
## Gender=Yes 32.625995 56.2500000 59.683377 2.702428e-02
## household_damage=No 33.614967 84.9085366 87.440633 1.679959e-02
## gina_steps=step3 17.708333 2.5914634 5.065963 1.946144e-04
## smoking_status=current smoker 19.760479 5.0304878 8.812665 1.185564e-05
## gina_control=partially controlled 29.260090 39.7865854 47.071240 3.667774e-06
## Hosptalization_last_year=Yes 13.186813 1.8292683 4.802111 2.694266e-06
## Ever_rhinitis=Yes 30.858469 60.8231707 68.232190 5.787715e-07
## smoking_status=former smokers 27.038627 28.8109756 36.886544 9.112187e-08
## gina_steps=step 1 or 2 22.255193 11.4329268 17.783641 6.683721e-08
## spt_any=No 26.429675 26.0670732 34.142480 5.082243e-08
## urbanization_level=No 28.397566 42.6829268 52.031662 3.098523e-09
## smoking_exposure_at_home=Yes 29.421769 52.7439024 62.058047 1.500440e-09
## gina_control=uncontrolled 18.531469 8.0792683 15.092348 1.067458e-10
## Emergency_last_year=Yes 18.627451 8.6890244 16.147757 2.460880e-11
## education=tertiary 14.830508 5.3353659 12.453826 4.994630e-13
## smoking_exposure_at_work=Yes 24.396783 27.7439024 39.366755 2.526618e-14
## XCOPD=Yes 10.833333 3.9634146 12.664908 3.390370e-19
## Cough=Yes 20.689655 20.1219512 33.667546 1.587363e-20
## irritant_triggered_asthma=Yes 11.307420 4.8780488 14.934037 6.887756e-22
## gina_steps=step4 or 5 5.027933 1.3719512 9.445910 4.463249e-23
## Chronic_productive_cough=Yes 15.201900 9.7560976 22.216359 2.072044e-23
## Recurrent_wheeze=Yes 14.769976 9.2987805 21.794195 6.232842e-24
## dyspenea=Yes 14.527845 9.1463415 21.794195 1.584008e-24
## emotion_triggered_asthma=Yes 2.453988 0.6097561 8.601583 6.490237e-26
## allergen_triggered_asthma=Yes 17.328520 14.6341463 29.234828 5.887110e-26
## severe_asthma=Yes 10.097720 4.7256098 16.200528 1.289689e-26
## Breathlessness=Yes 24.432263 47.5609756 67.387863 4.705226e-40
## exertion_triggered_asthma=Yes 19.882056 35.9756098 62.638522 6.536117e-68
## weather_triggered_asthma=Yes 8.595041 7.9268293 31.926121 1.781301e-68
## infection_triggered_asthma=Yes 18.528139 32.6219512 60.949868 1.007907e-75
## v.test
## infection_triggered_asthma=No 18.414351
## weather_triggered_asthma=No 17.487591
## exertion_triggered_asthma=No 17.413337
## Breathlessness=No 13.246853
## gina_steps=onlys saba or non users 11.863926
## severe_asthma=No 10.678038
## allergen_triggered_asthma=No 10.536131
## emotion_triggered_asthma=No 10.526952
## dyspenea=No 10.221783
## Recurrent_wheeze=No 10.088157
## Chronic_productive_cough=No 9.969531
## irritant_triggered_asthma=No 9.615346
## Cough=No 9.286974
## gina_control=controlled 9.277236
## XCOPD=No 8.955227
## smoking_exposure_at_work=No 7.620517
## smoking_status=never smoker 7.583328
## Emergency_last_year=No 6.675680
## smoking_exposure_at_home=No 6.044317
## urbanization_level=Yes 5.926292
## spt_any=Yes 5.448409
## Ever_rhinitis=No 4.998169
## Hosptalization_last_year=No 4.692849
## education=primary 4.440333
## household_damage=Yes 2.391065
## Gender=No 2.211167
## Gender=Yes -2.211167
## household_damage=No -2.391065
## gina_steps=step3 -3.725907
## smoking_status=current smoker -4.380226
## gina_control=partially controlled -4.629371
## Hosptalization_last_year=Yes -4.692849
## Ever_rhinitis=Yes -4.998169
## smoking_status=former smokers -5.343593
## gina_steps=step 1 or 2 -5.399472
## spt_any=No -5.448409
## urbanization_level=No -5.926292
## smoking_exposure_at_home=Yes -6.044317
## gina_control=uncontrolled -6.457075
## Emergency_last_year=Yes -6.675680
## education=tertiary -7.225445
## smoking_exposure_at_work=Yes -7.620517
## XCOPD=Yes -8.955227
## Cough=Yes -9.286974
## irritant_triggered_asthma=Yes -9.615346
## gina_steps=step4 or 5 -9.893027
## Chronic_productive_cough=Yes -9.969531
## Recurrent_wheeze=Yes -10.088157
## dyspenea=Yes -10.221783
## emotion_triggered_asthma=Yes -10.526952
## allergen_triggered_asthma=Yes -10.536131
## severe_asthma=Yes -10.678038
## Breathlessness=Yes -13.246853
## exertion_triggered_asthma=Yes -17.413337
## weather_triggered_asthma=Yes -17.487591
## infection_triggered_asthma=Yes -18.414351
##
## $`2`
## Cla/Mod Mod/Cla Global p.value
## exertion_triggered_asthma=Yes 50.96883 88.970588 62.638522 6.276032e-78
## infection_triggered_asthma=Yes 50.99567 86.617647 60.949868 1.134862e-71
## weather_triggered_asthma=Yes 64.13223 57.058824 31.926121 5.385008e-68
## allergen_triggered_asthma=Yes 59.74729 48.676471 29.234828 5.282532e-43
## Breathlessness=Yes 45.41895 85.294118 67.387863 3.990275e-38
## irritant_triggered_asthma=Yes 62.54417 26.029412 14.934037 4.091901e-23
## familial_allergy=Yes 45.74812 62.500000 49.023747 1.336596e-18
## emotion_triggered_asthma=Yes 67.48466 16.176471 8.601583 1.115098e-17
## spt_any=Yes 41.90705 76.911765 65.857520 1.270237e-14
## XCOPD=No 38.54985 93.823529 87.335092 2.970529e-11
## gina_steps=step 1 or 2 51.63205 25.588235 17.783641 6.747251e-11
## smoking_status=never smoker 41.01069 62.058824 54.300792 3.707076e-07
## gina_steps=step3 56.25000 7.941176 5.065963 3.307719e-05
## education=primary 40.43956 54.117647 48.021108 7.179033e-05
## severe_asthma=Yes 45.92834 20.735294 16.200528 7.760800e-05
## dyspenea=No 37.85425 82.500000 78.205805 6.260367e-04
## Hosptalization_last_year=No 36.69623 97.352941 95.197889 6.863295e-04
## gina_steps=step4 or 5 47.48603 12.500000 9.445910 8.369174e-04
## smoking_exposure_at_work=No 38.72933 65.441176 60.633245 1.317182e-03
## Recurrent_wheeze=Yes 42.13075 25.588235 21.794195 3.005074e-03
## urbanization_level=No 38.74239 56.176471 52.031662 6.914442e-03
## gina_control=partially controlled 38.56502 50.588235 47.071240 2.193519e-02
## nasal_plyposis=No 38.02423 60.000000 56.622691 2.644478e-02
## gina_control=uncontrolled 41.60839 17.500000 15.092348 2.991949e-02
## nasal_plyposis=Yes 33.09002 40.000000 43.377309 2.644478e-02
## urbanization_level=Yes 32.78328 43.823529 47.968338 6.914442e-03
## smoking_status=current smoker 25.74850 6.323529 8.812665 3.635641e-03
## Recurrent_wheeze=No 34.14305 74.411765 78.205805 3.005074e-03
## smoking_exposure_at_work=Yes 31.50134 34.558824 39.366755 1.317182e-03
## Hosptalization_last_year=Yes 19.78022 2.647059 4.802111 6.863295e-04
## dyspenea=Yes 28.81356 17.500000 21.794195 6.260367e-04
## smoking_status=former smokers 30.75823 31.617647 36.886544 3.578173e-04
## severe_asthma=No 33.94207 79.264706 83.799472 7.760800e-05
## gina_control=controlled 30.26499 31.911765 37.836412 6.474887e-05
## XCOPD=Yes 17.50000 6.176471 12.664908 2.970529e-11
## education=tertiary 15.67797 5.441176 12.453826 3.037803e-13
## spt_any=No 24.26584 23.088235 34.142480 1.270237e-14
## emotion_triggered_asthma=No 32.90993 83.823529 91.398417 1.115098e-17
## familial_allergy=No 26.39752 37.500000 50.976253 1.336596e-18
## gina_steps=onlys saba or non users 28.60483 53.970588 67.704485 2.811405e-21
## irritant_triggered_asthma=No 31.20347 73.970588 85.065963 4.091901e-23
## Breathlessness=No 16.18123 14.705882 32.612137 3.990275e-38
## allergen_triggered_asthma=No 26.02535 51.323529 70.765172 5.282532e-43
## weather_triggered_asthma=No 22.63566 42.941176 68.073879 5.385008e-68
## infection_triggered_asthma=No 12.29730 13.382353 39.050132 1.134862e-71
## exertion_triggered_asthma=No 10.59322 11.029412 37.361478 6.276032e-78
## v.test
## exertion_triggered_asthma=Yes 18.687344
## infection_triggered_asthma=Yes 17.902135
## weather_triggered_asthma=Yes 17.424422
## allergen_triggered_asthma=Yes 13.747356
## Breathlessness=Yes 12.909277
## irritant_triggered_asthma=Yes 9.901717
## familial_allergy=Yes 8.802619
## emotion_triggered_asthma=Yes 8.561395
## spt_any=Yes 7.708782
## XCOPD=No 6.648024
## gina_steps=step 1 or 2 6.526170
## smoking_status=never smoker 5.083415
## gina_steps=step3 4.151176
## education=primary 3.970273
## severe_asthma=Yes 3.951669
## dyspenea=No 3.420076
## Hosptalization_last_year=No 3.394983
## gina_steps=step4 or 5 3.340287
## smoking_exposure_at_work=No 3.212210
## Recurrent_wheeze=Yes 2.967218
## urbanization_level=No 2.700937
## gina_control=partially controlled 2.291488
## nasal_plyposis=No 2.219617
## gina_control=uncontrolled 2.171155
## nasal_plyposis=Yes -2.219617
## urbanization_level=Yes -2.700937
## smoking_status=current smoker -2.908158
## Recurrent_wheeze=No -2.967218
## smoking_exposure_at_work=Yes -3.212210
## Hosptalization_last_year=Yes -3.394983
## dyspenea=Yes -3.420076
## smoking_status=former smokers -3.569387
## severe_asthma=No -3.951669
## gina_control=controlled -3.994800
## XCOPD=Yes -6.648024
## education=tertiary -7.292711
## spt_any=No -7.708782
## emotion_triggered_asthma=No -8.561395
## familial_allergy=No -8.802619
## gina_steps=onlys saba or non users -9.469517
## irritant_triggered_asthma=No -9.901717
## Breathlessness=No -12.909277
## allergen_triggered_asthma=No -13.747356
## weather_triggered_asthma=No -17.424422
## infection_triggered_asthma=No -17.902135
## exertion_triggered_asthma=No -18.687344
##
##
## Link between the cluster variable and the quantitative variables
## ================================================================
## Eta2 P-value
## Age 0.401308860 1.713477e-211
## pack_years 0.381226938 6.147564e-198
## tlco 0.308406387 3.155157e-152
## kco 0.289487078 3.864506e-141
## onset_age_asthma 0.277129375 4.691434e-134
## FEV1_FVC_ratio_post 0.170767938 1.168361e-77
## Neutrophiles 0.075534558 5.402371e-33
## Reversibility 0.066991845 3.248075e-29
## Basophiles 0.066974672 3.305124e-29
## pd20 0.065987055 8.991640e-29
## Monocytes 0.062037201 4.870691e-27
## FeNO 0.058658324 1.461952e-25
## Eosinophiles 0.057340238 5.492890e-25
## BMI 0.044609271 1.783394e-19
## Lymphocytes 0.009686685 1.002067e-04
##
## Description of each cluster by quantitative variables
## =====================================================
## $`0`
## v.test Mean in category Overall mean sd in category
## Age 27.472299 6.505188e+01 4.971821e+01 9.190831e+00
## pack_years 26.833725 2.540905e+01 1.194451e+01 1.807577e+01
## onset_age_asthma 22.842245 3.534168e+01 2.149024e+01 1.892012e+01
## pd20 10.975641 2.870432e+03 1.952471e+03 1.993718e+03
## Neutrophiles 10.297112 4.361878e+00 3.856132e+00 1.578366e+00
## Monocytes 8.920045 4.752773e-01 4.264011e-01 1.847501e-01
## Reversibility 7.579384 9.399531e+00 7.333086e+00 9.873160e+00
## BMI 5.652998 2.804147e+01 2.706171e+01 4.802600e+00
## Basophiles 4.399938 3.856887e-02 3.133509e-02 4.954994e-02
## Eosinophiles 3.788147 2.418068e-01 2.196359e-01 1.886639e-01
## Lymphocytes 3.780324 2.074526e+00 1.982802e+00 9.077890e-01
## FeNO -2.517790 2.350760e+01 2.550929e+01 2.118177e+01
## FEV1_FVC_ratio_post -17.491063 7.102636e-01 7.699727e-01 1.185074e-01
## kco -22.352320 8.671352e+01 9.897243e+01 1.449915e+01
## tlco -23.803875 8.478481e+01 1.001420e+02 1.451667e+01
## Overall sd p.value
## Age 1.571245e+01 3.763074e-166
## pack_years 1.412548e+01 1.306309e-158
## onset_age_asthma 1.707061e+01 1.745247e-115
## pd20 2.354436e+03 5.004937e-28
## Neutrophiles 1.382643e+00 7.260871e-25
## Monocytes 1.542493e-01 4.660969e-19
## Reversibility 7.675073e+00 3.471989e-14
## BMI 4.879071e+00 1.576729e-08
## Basophiles 4.628193e-02 1.082819e-05
## Eosinophiles 1.647591e-01 1.517752e-04
## Lymphocytes 6.830395e-01 1.566246e-04
## FeNO 2.238045e+01 1.180938e-02
## FEV1_FVC_ratio_post 9.609862e-02 1.676026e-68
## kco 1.543910e+01 1.146301e-110
## tlco 1.816168e+01 3.045012e-125
##
## $`1`
## v.test Mean in category Overall mean sd in category
## FEV1_FVC_ratio_post 11.923228 8.061557e-01 7.699727e-01 6.547478e-02
## tlco 7.513166 1.044509e+02 1.001420e+02 1.258557e+01
## kco 4.365788 1.011010e+02 9.897243e+01 1.185596e+01
## pd20 -3.291206 1.707770e+03 1.952471e+03 2.892721e+03
## Lymphocytes -3.556162 1.906098e+00 1.982802e+00 5.438038e-01
## FeNO -7.845556 1.996448e+01 2.550929e+01 1.225226e+01
## BMI -9.055683 2.566645e+01 2.706171e+01 4.260206e+00
## Monocytes -9.632410 3.794817e-01 4.264011e-01 1.229169e-01
## Neutrophiles -10.215754 3.410091e+00 3.856132e+00 1.073498e+00
## Eosinophiles -10.348745 1.657927e-01 2.196359e-01 1.071583e-01
## Reversibility -10.919501 4.686543e+00 7.333086e+00 4.784212e+00
## Basophiles -11.218493 1.493902e-02 3.133509e-02 3.369966e-02
## onset_age_asthma -12.308406 1.485518e+01 2.149024e+01 1.186363e+01
## pack_years -13.876115 5.754874e+00 1.194451e+01 6.026262e+00
## Age -14.971583 4.228963e+01 4.971821e+01 1.366805e+01
## Overall sd p.value
## FEV1_FVC_ratio_post 9.609862e-02 8.956965e-33
## tlco 1.816168e+01 5.771430e-14
## kco 1.543910e+01 1.266651e-05
## pd20 2.354436e+03 9.975901e-04
## Lymphocytes 6.830395e-01 3.763121e-04
## FeNO 2.238045e+01 4.310409e-15
## BMI 4.879071e+00 1.357152e-19
## Monocytes 1.542493e-01 5.834464e-22
## Neutrophiles 1.382643e+00 1.685626e-24
## Eosinophiles 1.647591e-01 4.240090e-25
## Reversibility 7.675073e+00 9.300574e-28
## Basophiles 4.628193e-02 3.308618e-29
## onset_age_asthma 1.707061e+01 8.161903e-35
## pack_years 1.412548e+01 8.840776e-44
## Age 1.571245e+01 1.126085e-50
##
## $`2`
## v.test Mean in category Overall mean sd in category
## kco 16.921281 1.069966e+02 9.897243e+01 1.278873e+01
## tlco 15.179629 1.086096e+02 1.001420e+02 1.759758e+01
## FeNO 10.175386 3.250390e+01 2.550929e+01 2.828991e+01
## Basophiles 6.943793 4.120588e-02 3.133509e-02 4.955406e-02
## Eosinophiles 6.662796 2.533529e-01 2.196359e-01 1.759903e-01
## FEV1_FVC_ratio_post 4.803610 7.841511e-01 7.699727e-01 7.523409e-02
## Reversibility 3.624378 8.187483e+00 7.333086e+00 7.137742e+00
## BMI 3.607268 2.760228e+01 2.706171e+01 5.187577e+00
## pd20 -7.170721 1.433918e+03 1.952471e+03 1.757438e+03
## onset_age_asthma -9.509211 1.650441e+01 2.149024e+01 1.252902e+01
## Age -11.269770 4.427941e+01 4.971821e+01 1.273721e+01
## pack_years -11.749184 6.847037e+00 1.194451e+01 6.358852e+00
## Overall sd p.value
## kco 1.543910e+01 3.135346e-64
## tlco 1.816168e+01 4.825049e-52
## FeNO 2.238045e+01 2.553864e-24
## Basophiles 4.628193e-02 3.817099e-12
## Eosinophiles 1.647591e-01 2.686666e-11
## FEV1_FVC_ratio_post 9.609862e-02 1.558304e-06
## Reversibility 7.675073e+00 2.896573e-04
## BMI 4.879071e+00 3.094381e-04
## pd20 2.354436e+03 7.460355e-13
## onset_age_asthma 1.707061e+01 1.921148e-21
## Age 1.571245e+01 1.850517e-29
## pack_years 1.412548e+01 7.130402e-321.2.3 Radar Plots
1.2.4 parallel box plots
1.2.5 parallel coordinate plot
